The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics

Natural enzymes have evolved to perform their cellular functions under complex selective pressures, which often require their catalytic activities to be regulated by other proteins. We contrasted a natural enzyme, LovD, which acts on a protein-bound (LovF) acyl substrate, with a laboratory-generated...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiménez-Osés, Gonzalo, Osuna, Sílvia, Gao, Xue, Sawaya, Michael R., Gilson, Lynne, Collier, Steven J., Huisman, Gjalt W., Yeates, Todd O., Tang, Yi, Houk, K. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028369/
https://www.ncbi.nlm.nih.gov/pubmed/24727900
http://dx.doi.org/10.1038/nchembio.1503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028369/
https://www.ncbi.nlm.nih.gov/pubmed/24727900
http://dx.doi.org/10.1038/nchembio.1503

Ejemplares similares