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The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics
Natural enzymes have evolved to perform their cellular functions under complex selective pressures, which often require their catalytic activities to be regulated by other proteins. We contrasted a natural enzyme, LovD, which acts on a protein-bound (LovF) acyl substrate, with a laboratory-generated...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028369/ https://www.ncbi.nlm.nih.gov/pubmed/24727900 http://dx.doi.org/10.1038/nchembio.1503 |