Fluoxetine and norfluoxetine mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19 and CYP3A4

Fluoxetine and its circulating metabolite norfluoxetine present a complex multiple inhibitor system that causes reversible or time-dependent inhibition of CYP2D6, CYP3A4, and CYP2C19 in vitro. While significant inhibition of all three enzymes in vivo is predicted, midazolam and lovastatin AUCs were...

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Detalles Bibliográficos
Autores principales: Sager, Jennifer E, Lutz, Justin D, Foti, Robert S, Davis, Connie, Kunze, Kent L, Isoherranen, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029899/
https://www.ncbi.nlm.nih.gov/pubmed/24569517
http://dx.doi.org/10.1038/clpt.2014.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029899/
https://www.ncbi.nlm.nih.gov/pubmed/24569517
http://dx.doi.org/10.1038/clpt.2014.50

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