Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway

Pemetrexed is approved for first-line and maintenance treatment of patients with advanced or metastatic non-small-cell lung cancer (NSCLC). The protein kinase Akt/protein kinase B is a well-known regulator of cell survival which is activated by pemetrexed, but its role in pemetrexed-mediated cell de...

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Detalles Bibliográficos
Autores principales: Chen, Kun-Chieh, Yang, Tsung-Ying, Wu, Chun-Chi, Cheng, Chi-Chih, Hsu, Shih-Lan, Hung, Hsiao-Wen, Chen, Jian-Wei, Chang, Gee-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029963/
https://www.ncbi.nlm.nih.gov/pubmed/24847863
http://dx.doi.org/10.1371/journal.pone.0097888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029963/
https://www.ncbi.nlm.nih.gov/pubmed/24847863
http://dx.doi.org/10.1371/journal.pone.0097888

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