Targeting Oncoprotein Stability Overcomes Drug Resistance Caused by FLT3 Kinase Domain Mutations

FLT3 is the most frequently mutated kinase in acute myeloid leukemia (AML). Internal tandem duplications (ITDs) in the juxta-membrane region constitute the majority of activating FLT3 mutations. Several FLT3 kinase inhibitors were developed and tested in the clinic with significant success. However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Chuanjiang, Kancha, Rama Krishna, Duyster, Justus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029991/
https://www.ncbi.nlm.nih.gov/pubmed/24849514
http://dx.doi.org/10.1371/journal.pone.0097116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029991/
https://www.ncbi.nlm.nih.gov/pubmed/24849514
http://dx.doi.org/10.1371/journal.pone.0097116

Ejemplares similares