Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6

BACKGROUND: Conventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation. In contrast, targeting the upstream MAP kinase kinases, MKK3 and MKK6, partially maintains p38-mediated anti-inf...

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Detalles Bibliográficos
Autores principales: Hammaker, Deepa, Boyle, David L, Topolewski, Katharyn, Firestein, Gary S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030013/
https://www.ncbi.nlm.nih.gov/pubmed/24855454
http://dx.doi.org/10.1186/1476-9255-11-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030013/
https://www.ncbi.nlm.nih.gov/pubmed/24855454
http://dx.doi.org/10.1186/1476-9255-11-14

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