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Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6

BACKGROUND: Conventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation. In contrast, targeting the upstream MAP kinase kinases, MKK3 and MKK6, partially maintains p38-mediated anti-inf...

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Detalles Bibliográficos
Autores principales:	Hammaker, Deepa, Boyle, David L, Topolewski, Katharyn, Firestein, Gary S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030013/ https://www.ncbi.nlm.nih.gov/pubmed/24855454 http://dx.doi.org/10.1186/1476-9255-11-14

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