Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

Induction of heat shock protein (HSP)72 protects against obesity-induced insulin resistance, but the underlying mechanisms are unknown. Here, we show that HSP72 plays a pivotal role in increasing skeletal muscle mitochondrial number and oxidative metabolism. Mice overexpressing HSP72 in skeletal mus...

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Detalles Bibliográficos
Autores principales: Henstridge, Darren C., Bruce, Clinton R., Drew, Brian G., Tory, Kálmán, Kolonics, Attila, Estevez, Emma, Chung, Jason, Watson, Nadine, Gardner, Timothy, Lee-Young, Robert S., Connor, Timothy, Watt, Matthew J., Carpenter, Kevin, Hargreaves, Mark, McGee, Sean L., Hevener, Andrea L., Febbraio, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030108/
https://www.ncbi.nlm.nih.gov/pubmed/24430435
http://dx.doi.org/10.2337/db13-0967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030108/
https://www.ncbi.nlm.nih.gov/pubmed/24430435
http://dx.doi.org/10.2337/db13-0967

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