The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β

Microfibril-associated glycoprotein 1 (MAGP1) is a component of extracellular matrix microfibrils. Here we show that MAGP1 expression is significantly altered in obese humans, and inactivation of the MAGP1 gene (Mfap2(−/−)) in mice results in adipocyte hypertrophy and predisposition to metabolic dys...

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Detalles Bibliográficos
Autores principales: Craft, Clarissa S., Pietka, Terri A., Schappe, Timothy, Coleman, Trey, Combs, Michelle D., Klein, Samuel, Abumrad, Nada A., Mecham, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030109/
https://www.ncbi.nlm.nih.gov/pubmed/24458361
http://dx.doi.org/10.2337/db13-1604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030109/
https://www.ncbi.nlm.nih.gov/pubmed/24458361
http://dx.doi.org/10.2337/db13-1604

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