No evident dose-response relationship between cellular ROS level and its cytotoxicity – a paradoxical issue in ROS-based cancer therapy

Targeting cancer via ROS-based mechanism has been proposed as a radical therapeutic approach. Cancer cells exhibit higher endogenous oxidative stress than normal cells and pharmacological ROS insults via either enhancing ROS production or inhibiting ROS-scavenging activity can selectively kill cance...

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Detalles Bibliográficos
Autores principales: Zhu, Chunpeng, Hu, Wei, Wu, Hao, Hu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030257/
https://www.ncbi.nlm.nih.gov/pubmed/24848642
http://dx.doi.org/10.1038/srep05029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030257/
https://www.ncbi.nlm.nih.gov/pubmed/24848642
http://dx.doi.org/10.1038/srep05029

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