Ursolic Acid Inhibits Na(+)/K(+)-ATPase Activity and Prevents TNF-α-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis

Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, induce the expression of a wide variety of genes, including intercellular adhesion molecule-1 (ICAM-1). Ursolic acid (3β-hydroxy-urs-12-en-28-oic acid) was identified to inhibit the cell-surface ICAM-1 expression induced by pro-infla...

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Detalles Bibliográficos
Autores principales: Yokomichi, Tomonobu, Morimoto, Kyoko, Oshima, Nana, Yamada, Yuriko, Fu, Liwei, Taketani, Shigeru, Ando, Masayoshi, Kataoka, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030829/
https://www.ncbi.nlm.nih.gov/pubmed/24970122
http://dx.doi.org/10.3390/biom1010032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030829/
https://www.ncbi.nlm.nih.gov/pubmed/24970122
http://dx.doi.org/10.3390/biom1010032

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