The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

We have previously shown that treatment of androgen-sensitive LNCaP cells with the sphingosine kinase (SK) inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) induces the proteasomal degradation of two N-terminal variants of SK1 (SK1a and SK1b), increases C22:0-ceramide and diadenosine 5...

Descripción completa

Detalles Bibliográficos
Autores principales: Tonelli, Francesca, Alossaimi, Manal, Natarajan, Viswanathan, Gorshkova, Irina, Berdyshev, Evgeny, Bittman, Robert, Watson, David G., Pyne, Susan, Pyne, Nigel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030851/
https://www.ncbi.nlm.nih.gov/pubmed/24970170
http://dx.doi.org/10.3390/biom3020316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030851/
https://www.ncbi.nlm.nih.gov/pubmed/24970170
http://dx.doi.org/10.3390/biom3020316

Ejemplares similares