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Molecular Dynamics Simulations Capture the Misfolding of the Bovine Prion Protein at Acidic pH
Bovine spongiform encephalopathy (BSE), or mad cow disease, is a fatal neurodegenerative disease that is transmissible to humans and that is currently incurable. BSE is caused by the prion protein (PrP), which adopts two conformers; PrP(C) is the native innocuous form, which is α-helix rich; and PrP...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030982/ https://www.ncbi.nlm.nih.gov/pubmed/24970211 http://dx.doi.org/10.3390/biom4010181 |