Essential Plasticity and Redundancy of Metabolism Unveiled by Synthetic Lethality Analysis

We unravel how functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks. We perform an exhaustive computational screening of synthetic lethal reaction pairs in Escherichia coli in a minimal medium and we find that synthetic lethal pairs di...

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Detalles Bibliográficos
Autores principales: Güell, Oriol, Sagués, Francesc, Serrano, M. Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031049/
https://www.ncbi.nlm.nih.gov/pubmed/24854166
http://dx.doi.org/10.1371/journal.pcbi.1003637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031049/
https://www.ncbi.nlm.nih.gov/pubmed/24854166
http://dx.doi.org/10.1371/journal.pcbi.1003637

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