The Changing Geometry of a Fitness Landscape Along an Adaptive Walk

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a...

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Detalles Bibliográficos
Autores principales: Greene, Devin, Crona, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031059/
https://www.ncbi.nlm.nih.gov/pubmed/24853069
http://dx.doi.org/10.1371/journal.pcbi.1003520
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author Greene, Devin
Crona, Kristina
author_facet Greene, Devin
Crona, Kristina
author_sort Greene, Devin
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description It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
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spelling pubmed-40310592014-05-28 The Changing Geometry of a Fitness Landscape Along an Adaptive Walk Greene, Devin Crona, Kristina PLoS Comput Biol Research Article It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings. Public Library of Science 2014-05-22 /pmc/articles/PMC4031059/ /pubmed/24853069 http://dx.doi.org/10.1371/journal.pcbi.1003520 Text en © 2014 Greene, Crona http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Greene, Devin
Crona, Kristina
The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
title The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
title_full The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
title_fullStr The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
title_full_unstemmed The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
title_short The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
title_sort changing geometry of a fitness landscape along an adaptive walk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031059/
https://www.ncbi.nlm.nih.gov/pubmed/24853069
http://dx.doi.org/10.1371/journal.pcbi.1003520
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