Cargando…

Aberrant DNA Methylation in ES Cells

Both mouse and human embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. Using a new developmental tracing approach, we show that these cells are subject to massive aberrant CpG island de novo methylation that is exacerbated by differentiation in vitro. Bi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ludwig, Guy, Nejman, Deborah, Hecht, Merav, Orlanski, Shari, Abu-Remaileh, Monther, Yanuka, Ofra, Sandler, Oded, Marx, Amichai, Roberts, Douglas, Benvenisty, Nissim, Bergman, Yehudit, Mendelsohn, Monica, Cedar, Howard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031077/ https://www.ncbi.nlm.nih.gov/pubmed/24852222 http://dx.doi.org/10.1371/journal.pone.0096090

Ejemplares similares

Teratogen screening using transcriptome profiling of differentiating human embryonic stem cells
por: Mayshar, Yoav, et al.
Publicado: (2011)

Embryonic Stem Cell (ES)-Specific Enhancers Specify the Expression Potential of ES Genes in Cancer
por: Aran, Dvir, et al.
Publicado: (2016)

Genome-wide screening for genes involved in the epigenetic basis of fragile X syndrome
por: Vershkov, Dan, et al.
Publicado: (2022)

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation
por: Halevy, Tomer, et al.
Publicado: (2016)

Differentiation of uniparental human embryonic stem cells into granulosa cells reveals a paternal contribution to gonadal development
por: Keshet, Gal, et al.
Publicado: (2023)

Genome-wide Screen for Culture Adaptation and Tumorigenicity-Related Genes in Human Pluripotent Stem Cells
por: Weissbein, Uri, et al.
Publicado: (2019)

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
por: Epsztejn-Litman, Silvina, et al.
Publicado: (2008)

Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells
por: Avior, Yishai, et al.
Publicado: (2017)

Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells
por: Bar, Shiran, et al.
Publicado: (2021)

Large-scale analysis of imprinting in naive human pluripotent stem cells reveals recurrent aberrations and a potential link to FGF signaling
por: Keshet, Gal, et al.
Publicado: (2021)

Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq
por: Weissbein, Uri, et al.
Publicado: (2016)

Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells
por: Weissbein, Uri, et al.
Publicado: (2017)

Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
por: Bergman, Yehudit, et al.
Publicado: (2021)

Gender-specific postnatal demethylation and establishment of epigenetic memory
por: Reizel, Yitzhak, et al.
Publicado: (2015)

Biallelic Germline Transcription at the κ Immunoglobulin Locus
por: Singh, Nandita, et al.
Publicado: (2003)

Muscle injury causes long-term changes in stem-cell DNA methylation
por: Falick Michaeli, Tal, et al.
Publicado: (2022)

WWOX somatic ablation in skeletal muscles alters glucose metabolism
por: Abu-Remaileh, Muhannad, et al.
Publicado: (2019)

A Novel Pax5-Binding Regulatory Element in the Igκ Locus
por: Levin-Klein, Rena, et al.
Publicado: (2014)

Studying Early Lethality of 45,XO (Turner's Syndrome) Embryos Using Human Embryonic Stem Cells
por: Urbach, Achia, et al.
Publicado: (2009)

The Tumorigenic Potential of Human Pluripotent Stem Cells
por: Lezmi, Elyad, et al.
Publicado: (2022)

Bright/Arid3A Acts as a Barrier to Somatic Cell Reprogramming through Direct Regulation of Oct4, Sox2, and Nanog
por: Popowski, Melissa, et al.
Publicado: (2014)

Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
por: Braverman-Gross, Carmel, et al.
Publicado: (2021)

Large-Scale Analysis of X Inactivation Variations between Primed and Naïve Human Embryonic Stem Cells
por: Sarel-Gallily, Roni, et al.
Publicado: (2022)

Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells
por: Halevy, Tomer, et al.
Publicado: (2014)

Genome maintenance in pluripotent stem cells
por: Weissbein, Uri, et al.
Publicado: (2014)

TeratoScore: Assessing the Differentiation Potential of Human Pluripotent Stem Cells by Quantitative Expression Analysis of Teratomas
por: Avior, Yishai, et al.
Publicado: (2015)

Genome‐wide screen for anticancer drug resistance in haploid human embryonic stem cells
por: Segal, Emanuel, et al.
Publicado: (2023)

Ferroptosis regulation by the NGLY1/NFE2L1 pathway
por: Forcina, Giovanni C., et al.
Publicado: (2022)

The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells
por: Viner-Breuer, Ruth, et al.
Publicado: (2019)

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation
por: Lezmi, Elyad, et al.
Publicado: (2020)

Global Indiscriminate Methylation in Cell-Specific Gene Promoters following Reprogramming into Human Induced Pluripotent Stem Cells
por: Nissenbaum, Jonathan, et al.
Publicado: (2013)

Genome-Wide Screening in Human Embryonic Stem Cells Highlights the Hippo Signaling Pathway as Granting Synthetic Viability in ATM Deficiency
por: Viner-Breuer, Ruth, et al.
Publicado: (2023)

Generation, genomic characterization, and differentiation of triploid human embryonic stem cells
por: Haim-Abadi, Guy, et al.
Publicado: (2023)

Smooth Pursuit Eye Movement of Monkeys Naive to Laboratory Setups With Pictures and Artificial Stimuli
por: Botschko, Yehudit, et al.
Publicado: (2018)

Identification of Novel Imprinted Differentially Methylated Regions by Global Analysis of Human-Parthenogenetic-Induced Pluripotent Stem Cells
por: Stelzer, Yonatan, et al.
Publicado: (2013)

Clonally stable Vκ allelic choice instructs Igκ repertoire
por: Levin-Klein, Rena, et al.
Publicado: (2017)

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
por: Pedram, Kayvon, et al.
Publicado: (2022)

Chromosomal coordination and differential structure of asynchronous replicating regions
por: Blumenfeld, Britny, et al.
Publicado: (2021)

Qué es la herencia judía
por: Lewisohn, Ludwig, 1882-1955
Publicado: (1965)

An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation
por: Scharenberg, Samantha G., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_efujnsv8viu9t2kre2dammut3b