Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

BACKGROUND: The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is n...

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Detalles Bibliográficos
Autores principales: Trochine, Andrea, Creek, Darren J., Faral-Tello, Paula, Barrett, Michael P., Robello, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031082/
https://www.ncbi.nlm.nih.gov/pubmed/24853684
http://dx.doi.org/10.1371/journal.pntd.0002844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031082/
https://www.ncbi.nlm.nih.gov/pubmed/24853684
http://dx.doi.org/10.1371/journal.pntd.0002844

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