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Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
BACKGROUND: The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is n...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031082/ https://www.ncbi.nlm.nih.gov/pubmed/24853684 http://dx.doi.org/10.1371/journal.pntd.0002844 |