Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Metabolic pathways used by Mycobacterium tuberculosis (Mtb) to establish and maintain infections are important for our understanding of pathogenesis and the development of new chemotherapies. To investigate the role of fructose-1,6-bisphosphate aldolase (FBA), we engineered an Mtb strain in which FB...

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Detalles Bibliográficos
Autores principales: Puckett, Susan, Trujillo, Carolina, Eoh, Hyungjin, Marrero, Joeli, Spencer, John, Jackson, Mary, Schnappinger, Dirk, Rhee, Kyu, Ehrt, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031216/
https://www.ncbi.nlm.nih.gov/pubmed/24851864
http://dx.doi.org/10.1371/journal.ppat.1004144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031216/
https://www.ncbi.nlm.nih.gov/pubmed/24851864
http://dx.doi.org/10.1371/journal.ppat.1004144

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