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Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis
Metabolic pathways used by Mycobacterium tuberculosis (Mtb) to establish and maintain infections are important for our understanding of pathogenesis and the development of new chemotherapies. To investigate the role of fructose-1,6-bisphosphate aldolase (FBA), we engineered an Mtb strain in which FB...
Autores principales: | Puckett, Susan, Trujillo, Carolina, Eoh, Hyungjin, Marrero, Joeli, Spencer, John, Jackson, Mary, Schnappinger, Dirk, Rhee, Kyu, Ehrt, Sabine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031216/ https://www.ncbi.nlm.nih.gov/pubmed/24851864 http://dx.doi.org/10.1371/journal.ppat.1004144 |
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