Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations

Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The protective effects of FTY720 in EAE are primarily...

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Detalles Bibliográficos
Autores principales: Sheridan, Graham K., Dev, Kumlesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031479/
https://www.ncbi.nlm.nih.gov/pubmed/24851861
http://dx.doi.org/10.1038/srep05051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031479/
https://www.ncbi.nlm.nih.gov/pubmed/24851861
http://dx.doi.org/10.1038/srep05051

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