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Protein Splicing: How Inteins Escape from Precursor Proteins

Inteins are nature's escape artists; they facilitate their excision from flanking polypeptides (exteins) concomitant with extein ligation to produce a mature host protein. Splicing requires sequential nucleophilic displacement reactions catalyzed by strategies similar to proteases and asparagin...

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Detalles Bibliográficos
Autores principales: Mills, Kenneth V., Johnson, Margaret A., Perler, Francine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031507/
https://www.ncbi.nlm.nih.gov/pubmed/24695729
http://dx.doi.org/10.1074/jbc.R113.540310