MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability

Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion of HR in G1 cells can lead to the loss-of-heteroz...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Young Eun, Pan, Yunfeng, Park, Eunmi, Konstantinopoulos, Panagiotis, De, Subhajyoti, D'Andrea, Alan, Chowdhury, Dipanjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031983/
https://www.ncbi.nlm.nih.gov/pubmed/24843000
http://dx.doi.org/10.7554/eLife.02445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031983/
https://www.ncbi.nlm.nih.gov/pubmed/24843000
http://dx.doi.org/10.7554/eLife.02445

Ejemplares similares