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MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability

Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion of HR in G1 cells can lead to the loss-of-heteroz...

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Detalles Bibliográficos
Autores principales:	Choi, Young Eun, Pan, Yunfeng, Park, Eunmi, Konstantinopoulos, Panagiotis, De, Subhajyoti, D'Andrea, Alan, Chowdhury, Dipanjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031983/ https://www.ncbi.nlm.nih.gov/pubmed/24843000 http://dx.doi.org/10.7554/eLife.02445

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