Cargando…
A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape
Mutations are central to evolution, providing the genetic variation upon which selection acts. A mutation’s effect on the suitability of a gene to perform a particular function (gene fitness) can be positive, negative, or neutral. Knowledge of the distribution of fitness effects (DFE) of mutations i...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032126/ https://www.ncbi.nlm.nih.gov/pubmed/24567513 http://dx.doi.org/10.1093/molbev/msu081 |