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A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape

Mutations are central to evolution, providing the genetic variation upon which selection acts. A mutation’s effect on the suitability of a gene to perform a particular function (gene fitness) can be positive, negative, or neutral. Knowledge of the distribution of fitness effects (DFE) of mutations i...

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Detalles Bibliográficos
Autores principales: Firnberg, Elad, Labonte, Jason W., Gray, Jeffrey J., Ostermeier, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032126/
https://www.ncbi.nlm.nih.gov/pubmed/24567513
http://dx.doi.org/10.1093/molbev/msu081