Nitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity

[Image: see text] Overproduction of NO by nNOS is implicated in the pathogenesis of diverse neuronal disorders. Since NO signaling is involved in diverse physiological functions, selective inhibition of nNOS over other isoforms is essential to minimize side effects. A series of α-amino functionalize...

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Detalles Bibliográficos
Autores principales: Kang, Soosung, Tang, Wei, Li, Huiying, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032192/
https://www.ncbi.nlm.nih.gov/pubmed/24758147
http://dx.doi.org/10.1021/jm5004182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032192/
https://www.ncbi.nlm.nih.gov/pubmed/24758147
http://dx.doi.org/10.1021/jm5004182

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