Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino Acid

[Image: see text] P-glycoprotein (P-gp) serves as a therapeutic target for the development of multidrug resistance reversal agents. In this study, we synthesized 21 novel compounds by peptide coupling at corresponding carboxyl and amino termini of (S)-valine-based bis-thiazole and monothiazole deriv...

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Detalles Bibliográficos
Autores principales: Singh, Satyakam, Prasad, Nagarajan Rajendra, Chufan, Eduardo E., Patel, Bhargav A., Wang, Yi-Jun, Chen, Zhe-Sheng, Ambudkar, Suresh V., Talele, Tanaji T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032198/
https://www.ncbi.nlm.nih.gov/pubmed/24773054
http://dx.doi.org/10.1021/jm401966m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032198/
https://www.ncbi.nlm.nih.gov/pubmed/24773054
http://dx.doi.org/10.1021/jm401966m

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