Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

BACKGROUND: Clinical specimens undergoing diagnostic molecular pathology testing are fixed in formalin due to the necessity for detailed morphological assessment. However, formalin fixation can cause major issues with molecular testing, as it causes DNA damage such as fragmentation and non-reproduci...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Stephen Q, Li, Jason, Tan, Angela Y-C, Vedururu, Ravikiran, Pang, Jia-Min B, Do, Hongdo, Ellul, Jason, Doig, Ken, Bell, Anthony, MacArthur, Grant A, Fox, Stephen B, Thomas, David M, Fellowes, Andrew, Parisot, John P, Dobrovic, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032349/
https://www.ncbi.nlm.nih.gov/pubmed/24885028
http://dx.doi.org/10.1186/1755-8794-7-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032349/
https://www.ncbi.nlm.nih.gov/pubmed/24885028
http://dx.doi.org/10.1186/1755-8794-7-23

Ejemplares similares