Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

We elucidate the molecular mechanisms of two distinct activation strategies (autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic allosteric activation is in play where either activation loop phosphorylation or TPX2 binding to a conserved hydrophobic groove shifts the...

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Detalles Bibliográficos
Autores principales: Zorba, Adelajda, Buosi, Vanessa, Kutter, Steffen, Kern, Nadja, Pontiggia, Francesco, Cho, Young-Jin, Kern, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032492/
https://www.ncbi.nlm.nih.gov/pubmed/24867643
http://dx.doi.org/10.7554/eLife.02667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032492/
https://www.ncbi.nlm.nih.gov/pubmed/24867643
http://dx.doi.org/10.7554/eLife.02667

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