Cargando…

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

We elucidate the molecular mechanisms of two distinct activation strategies (autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic allosteric activation is in play where either activation loop phosphorylation or TPX2 binding to a conserved hydrophobic groove shifts the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zorba, Adelajda, Buosi, Vanessa, Kutter, Steffen, Kern, Nadja, Pontiggia, Francesco, Cho, Young-Jin, Kern, Dorothee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032492/ https://www.ncbi.nlm.nih.gov/pubmed/24867643 http://dx.doi.org/10.7554/eLife.02667

Ejemplares similares

Dynamics of human protein kinase Aurora A linked to drug selectivity
por: Pitsawong, Warintra, et al.
Publicado: (2018)

Ancient Origins of Allosteric Activation in a Ser/Thr Kinase
por: Hadzipasic, Adelajda, et al.
Publicado: (2020)

A biophysical framework for double-drugging kinases
por: Kim, Chansik, et al.
Publicado: (2023)

The structural basis of the multi-step allosteric activation of Aurora B kinase
por: Segura-Peña, Dario, et al.
Publicado: (2023)

Human TPX2 is required for targeting Aurora-A kinase to the spindle
por: Kufer, Thomas A., et al.
Publicado: (2002)

A critical evaluation of protein kinase regulation by activation loop autophosphorylation
por: Reinhardt, Ronja, et al.
Publicado: (2023)

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
por: Chen, Huaibin, et al.
Publicado: (2017)

The multifaceted allosteric regulation of Aurora kinase A
por: Levinson, Nicholas Mark
Publicado: (2018)

Structural insight into TPX2-stimulated microtubule assembly
por: Zhang, Rui, et al.
Publicado: (2017)

Two TPX2-Dependent Switches Control the Activity of Aurora A
por: Xu, Xue, et al.
Publicado: (2011)

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex
por: Asteriti, Italia Anna, et al.
Publicado: (2017)

The energy landscape of adenylate kinase during catalysis
por: Kerns, S. Jordan, et al.
Publicado: (2015)

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli
por: Zimanyi, Christina M, et al.
Publicado: (2016)

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells
por: van Gijn, Stephanie E., et al.
Publicado: (2018)

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
por: Cole, Daniel J., et al.
Publicado: (2017)

Phosphorylation of p53 Is Regulated by TPX2-Aurora A in Xenopus Oocytes
por: Pascreau, Gaetan, et al.
Publicado: (2009)

Allosteric regulation of kinase activity in living cells
por: Godbole, Shivani Sujay, et al.
Publicado: (2023)

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
por: Bhattacharyya, Moitrayee, et al.
Publicado: (2020)

CaMKII autophosphorylation can occur between holoenzymes without subunit exchange
por: Lučić, Iva, et al.
Publicado: (2023)

Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division
por: Garrido, Georgina, et al.
Publicado: (2016)

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor
por: Shivnaraine, Rabindra V, et al.
Publicado: (2016)

Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite
por: Clingman, Carina C, et al.
Publicado: (2014)

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate
por: MacKinnon, Andrew L, et al.
Publicado: (2014)

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
por: Janeček, Matej, et al.
Publicado: (2016)

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
por: Aguirre, Tim, et al.
Publicado: (2023)

Urochordate Ascidians Possess a Single Isoform of Aurora Kinase That Localizes to the Midbody via TPX2 in Eggs and Cleavage Stage Embryos
por: Hebras, Celine, et al.
Publicado: (2012)

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
por: Burgess, Selena G., et al.
Publicado: (2016)

Dimerization facilitates the conformational transitions for bacterial phosphotransferase enzyme I autophosphorylation in an allosteric manner
por: Lee, Ko On, et al.
Publicado: (2017)

WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin
por: Huang, Junjie, et al.
Publicado: (2021)

CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis
por: Oh, Wonkyung, et al.
Publicado: (2022)

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
por: Harrison, Joseph S, et al.
Publicado: (2016)

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ
por: Mensa, Bruk, et al.
Publicado: (2021)

Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis
por: Kachaner, David, et al.
Publicado: (2014)

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
por: Ruff, Emily F, et al.
Publicado: (2018)

Autophosphorylation and Self-Activation of DNA-Dependent Protein Kinase
por: Kurosawa, Aya
Publicado: (2021)

Structural insights into the light-driven auto-assembly process of the water-oxidizing Mn(4)CaO(5)-cluster in photosystem II
por: Zhang, Miao, et al.
Publicado: (2017)

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A
por: Bird, Alexander W., et al.
Publicado: (2008)

PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size
por: Sobajima, Tomoaki, et al.
Publicado: (2023)

Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II
por: Bhattacharyya, Moitrayee, et al.
Publicado: (2016)

Energetic dissection of Gleevec’s selectivity towards human tyrosine kinases
por: Agafonov, R.V., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fgl6mect5brcge8k20ppu45u6k