Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome

OBJECTIVE: The TGF-β pathway plays a central role in joint development with polymorphism in TGF-β pathway genes implicated in osteoarthritis susceptibility. One association is to rs12901499, within intron 1 of SMAD3. Since rs12901499 is not in linkage disequilibrium with a non-synonymous polymorphis...

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Detalles Bibliográficos
Autores principales: Raine, E.V.A., Reynard, L.N., van de Laar, I.M.B.H., Bertoli-Avella, A.M., Loughlin, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032576/
https://www.ncbi.nlm.nih.gov/pubmed/24583347
http://dx.doi.org/10.1016/j.joca.2014.02.931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032576/
https://www.ncbi.nlm.nih.gov/pubmed/24583347
http://dx.doi.org/10.1016/j.joca.2014.02.931

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