Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity

In mammals, extended periods of fasting leads to the accumulation of blood ketone bodies including acetoacetate. Here we show that similar to the conversion of leucine to acetoacetate in fasting mammals, starvation conditions induced ketone body-like acetic acid generation from leucine in S. cerevis...

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Detalles Bibliográficos
Autores principales: Hu, Jia, Wei, Min, Mirzaei, Hamed, Madia, Federica, Amparo, Mario, Chagoury, Shawna, Kennedy, Brian, Longo, Valter D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032597/
https://www.ncbi.nlm.nih.gov/pubmed/24649827
http://dx.doi.org/10.1111/acel.12202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032597/
https://www.ncbi.nlm.nih.gov/pubmed/24649827
http://dx.doi.org/10.1111/acel.12202

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