Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in...

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Detalles Bibliográficos
Autores principales: Miller, Richard A, Harrison, David E, Astle, Clinton M, Fernandez, Elizabeth, Flurkey, Kevin, Han, Melissa, Javors, Martin A, Li, Xinna, Nadon, Nancy L, Nelson, James F, Pletcher, Scott, Salmon, Adam B, Sharp, Zelton Dave, Van Roekel, Sabrina, Winkleman, Lynn, Strong, Randy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032600/
https://www.ncbi.nlm.nih.gov/pubmed/24341993
http://dx.doi.org/10.1111/acel.12194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032600/
https://www.ncbi.nlm.nih.gov/pubmed/24341993
http://dx.doi.org/10.1111/acel.12194

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