P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion

p44 is a short isoform of p53 with ‘longevity-assurance’ activity. Overexpression of p44 in the mouse (p44(+/+) transgenic mice) causes a progeroid phenotype that mimics an accelerated form of aging. The phenotype includes abnormal phosphorylation of the microtubule-binding protein tau, synaptic def...

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Detalles Bibliográficos
Autores principales: Pehar, Mariana, Ko, Mi Hee, Li, Mi, Scrable, Heidi, Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032616/
https://www.ncbi.nlm.nih.gov/pubmed/24341977
http://dx.doi.org/10.1111/acel.12192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032616/
https://www.ncbi.nlm.nih.gov/pubmed/24341977
http://dx.doi.org/10.1111/acel.12192

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