Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies

The Drosophila Indy (I'm Not Dead Yet) gene encodes a plasma membrane transporter of Krebs cycle intermediates, with robust expression in tissues associated with metabolism. Reduced INDY alters metabolism and extends longevity in a manner similar to caloric restriction (CR); however, little is...

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Detalles Bibliográficos
Autores principales: Rogers, Ryan P., Rogina, Blanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032799/
https://www.ncbi.nlm.nih.gov/pubmed/24827528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032799/
https://www.ncbi.nlm.nih.gov/pubmed/24827528

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