IDH1(R132H) Mutation Increases U87 Glioma Cell Sensitivity to Radiation Therapy in Hypoxia

Objective. IDH1 codon 132 mutation (mostly Arg132His) is frequently found in gliomas and is associated with longer survival. However, it is still unclear whether IDH1 mutation renders the cell more vulnerable to current treatment, radio- and chemotherapy. Materials and Methods. We transduced U87 wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiao-Wei, Labussière, Marianne, Valable, Samuel, Pérès, Elodie A., Guillamo, Jean-Sébastien, Bernaudin, Myriam, Sanson, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033346/
https://www.ncbi.nlm.nih.gov/pubmed/24895549
http://dx.doi.org/10.1155/2014/198697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033346/
https://www.ncbi.nlm.nih.gov/pubmed/24895549
http://dx.doi.org/10.1155/2014/198697

Ejemplares similares