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IDH1(R132H) Mutation Increases U87 Glioma Cell Sensitivity to Radiation Therapy in Hypoxia
Objective. IDH1 codon 132 mutation (mostly Arg132His) is frequently found in gliomas and is associated with longer survival. However, it is still unclear whether IDH1 mutation renders the cell more vulnerable to current treatment, radio- and chemotherapy. Materials and Methods. We transduced U87 wit...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033346/ https://www.ncbi.nlm.nih.gov/pubmed/24895549 http://dx.doi.org/10.1155/2014/198697 |