Cargando…
The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines
All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15–25 years of use, due to slow progressive subtle inflammation at the bone implant interface. This inflammatory disease state is caused by implant debris acting, primarily, on inna...
Autores principales: | Landgraeber, Stefan, Jäger, Marcus, Jacobs, Joshua J., Hallab, Nadim James |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033543/ https://www.ncbi.nlm.nih.gov/pubmed/24891761 http://dx.doi.org/10.1155/2014/185150 |
Ejemplares similares
-
Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris
por: Hallab, Nadim J., et al.
Publicado: (2017) -
Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation
por: Samelko, Lauryn, et al.
Publicado: (2016) -
The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
por: Hallab, Nadim James, et al.
Publicado: (2019) -
Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure
por: Samelko, Lauryn, et al.
Publicado: (2013) -
Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants
por: Samelko, Lauryn, et al.
Publicado: (2019)