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Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds

Plantagoside (5,7,4′,5′-tetrahydroxyflavanone-3′-O-glucoside) and its aglycone (5,7,3′,4′,5′-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the for...

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Autores principales: Matsuura, Nobuyasu, Aradate, Tadashi, Kurosaka, Chihiro, Ubukata, Makoto, Kittaka, Shiho, Nakaminami, Yuri, Gamo, Kanae, Kojima, Hiroyuki, Ohara, Mitsuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033550/
https://www.ncbi.nlm.nih.gov/pubmed/24895551
http://dx.doi.org/10.1155/2014/208539
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author Matsuura, Nobuyasu
Aradate, Tadashi
Kurosaka, Chihiro
Ubukata, Makoto
Kittaka, Shiho
Nakaminami, Yuri
Gamo, Kanae
Kojima, Hiroyuki
Ohara, Mitsuharu
author_facet Matsuura, Nobuyasu
Aradate, Tadashi
Kurosaka, Chihiro
Ubukata, Makoto
Kittaka, Shiho
Nakaminami, Yuri
Gamo, Kanae
Kojima, Hiroyuki
Ohara, Mitsuharu
author_sort Matsuura, Nobuyasu
collection PubMed
description Plantagoside (5,7,4′,5′-tetrahydroxyflavanone-3′-O-glucoside) and its aglycone (5,7,3′,4′,5′-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation. These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications.
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spelling pubmed-40335502014-06-03 Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds Matsuura, Nobuyasu Aradate, Tadashi Kurosaka, Chihiro Ubukata, Makoto Kittaka, Shiho Nakaminami, Yuri Gamo, Kanae Kojima, Hiroyuki Ohara, Mitsuharu Biomed Res Int Research Article Plantagoside (5,7,4′,5′-tetrahydroxyflavanone-3′-O-glucoside) and its aglycone (5,7,3′,4′,5′-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation. These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications. Hindawi Publishing Corporation 2014 2014-05-07 /pmc/articles/PMC4033550/ /pubmed/24895551 http://dx.doi.org/10.1155/2014/208539 Text en Copyright © 2014 Nobuyasu Matsuura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matsuura, Nobuyasu
Aradate, Tadashi
Kurosaka, Chihiro
Ubukata, Makoto
Kittaka, Shiho
Nakaminami, Yuri
Gamo, Kanae
Kojima, Hiroyuki
Ohara, Mitsuharu
Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
title Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
title_full Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
title_fullStr Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
title_full_unstemmed Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
title_short Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
title_sort potent protein glycation inhibition of plantagoside in plantago major seeds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033550/
https://www.ncbi.nlm.nih.gov/pubmed/24895551
http://dx.doi.org/10.1155/2014/208539
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