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Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds
Plantagoside (5,7,4′,5′-tetrahydroxyflavanone-3′-O-glucoside) and its aglycone (5,7,3′,4′,5′-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the for...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033550/ https://www.ncbi.nlm.nih.gov/pubmed/24895551 http://dx.doi.org/10.1155/2014/208539 |
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author | Matsuura, Nobuyasu Aradate, Tadashi Kurosaka, Chihiro Ubukata, Makoto Kittaka, Shiho Nakaminami, Yuri Gamo, Kanae Kojima, Hiroyuki Ohara, Mitsuharu |
author_facet | Matsuura, Nobuyasu Aradate, Tadashi Kurosaka, Chihiro Ubukata, Makoto Kittaka, Shiho Nakaminami, Yuri Gamo, Kanae Kojima, Hiroyuki Ohara, Mitsuharu |
author_sort | Matsuura, Nobuyasu |
collection | PubMed |
description | Plantagoside (5,7,4′,5′-tetrahydroxyflavanone-3′-O-glucoside) and its aglycone (5,7,3′,4′,5′-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation. These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications. |
format | Online Article Text |
id | pubmed-4033550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40335502014-06-03 Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds Matsuura, Nobuyasu Aradate, Tadashi Kurosaka, Chihiro Ubukata, Makoto Kittaka, Shiho Nakaminami, Yuri Gamo, Kanae Kojima, Hiroyuki Ohara, Mitsuharu Biomed Res Int Research Article Plantagoside (5,7,4′,5′-tetrahydroxyflavanone-3′-O-glucoside) and its aglycone (5,7,3′,4′,5′-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation. These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications. Hindawi Publishing Corporation 2014 2014-05-07 /pmc/articles/PMC4033550/ /pubmed/24895551 http://dx.doi.org/10.1155/2014/208539 Text en Copyright © 2014 Nobuyasu Matsuura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Matsuura, Nobuyasu Aradate, Tadashi Kurosaka, Chihiro Ubukata, Makoto Kittaka, Shiho Nakaminami, Yuri Gamo, Kanae Kojima, Hiroyuki Ohara, Mitsuharu Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds |
title | Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds |
title_full | Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds |
title_fullStr | Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds |
title_full_unstemmed | Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds |
title_short | Potent Protein Glycation Inhibition of Plantagoside in Plantago major Seeds |
title_sort | potent protein glycation inhibition of plantagoside in plantago major seeds |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033550/ https://www.ncbi.nlm.nih.gov/pubmed/24895551 http://dx.doi.org/10.1155/2014/208539 |
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