Cargando…

A Computer Simulation Approach to Assessing Therapeutic Intervention Points for the Prevention of Cytokine-Induced Cartilage Breakdown

OBJECTIVE: To use a novel computational approach to examine the molecular pathways involved in cartilage breakdown and to use computer simulation to test possible interventions for reducing collagen release. METHODS: We constructed a computational model of the relevant molecular pathways using the S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Proctor, CJ, Macdonald, C, Milner, JM, Rowan, AD, Cawston, TE
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Chondrocyte Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033570/ https://www.ncbi.nlm.nih.gov/pubmed/24757149 http://dx.doi.org/10.1002/art.38297

Ejemplares similares

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis
por: Gossan, Nicole, et al.
Publicado: (2013)

Fibroblast Growth Factor 2 Drives Changes in Gene Expression Following Injury to Murine Cartilage In Vitro and In Vivo
por: Chong, Ka-Wing, et al.
Publicado: (2013)

Sphingosine 1-Phosphate Counteracts the Effects of Interleukin-1β in Human Chondrocytes
por: Stradner, Martin H, et al.
Publicado: (2013)

Evaluation of chondrocyte micromass culture for the study of cartilage degradation
por: Morgan, TG, et al.
Publicado: (2005)

Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases
por: Cawston, TE, et al.
Publicado: (2005)

Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis
por: Milner, Jennifer M, et al.
Publicado: (2006)

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
por: Hui, Wang, et al.
Publicado: (2016)

Synergistic interactions of proinflammatory cytokines with oncostatin M: production of active collagenases and implications for joint destruction
por: Cawston, TE
Publicado: (2004)

Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction
por: Cawston, T, et al.
Publicado: (2003)

Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases
por: Song, Zongmian, et al.
Publicado: (2021)

A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL
por: Hui, Wang, et al.
Publicado: (2005)

Cartilage breakdown in microgravity—a problem for long-term spaceflight?
por: Fitzgerald, Jamie
Publicado: (2017)

Plant N-glycan breakdown by human gut Bacteroides
por: Crouch, Lucy I., et al.
Publicado: (2022)

Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
por: Nagase, H, et al.
Publicado: (2005)

Diverse mating consequences of the evolutionary breakdown of the sexual polymorphism heterostyly
por: Yuan, Shuai, et al.
Publicado: (2023)

Biogenesis and Breakdown of Lipid Droplets in Pathological Conditions
por: Fader Kaiser, Claudio M., et al.
Publicado: (2022)

Analysis and simulation of the "after-pulse" RF breakdown
por: Lin, Xiancai, et al.
Publicado: (2019)

The breakdown of the cytokine network subsequent to human immunodeficiency virus infection
por: Clerici, M., et al.
Publicado: (1995)

Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma
por: Riegger, Jana, et al.
Publicado: (2017)

TIMP-3 inhibits aggrecan breakdown in pig articular cartilage stimulated with IL-1
por: Nagase, H, et al.
Publicado: (2003)

Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis
por: Lauzier, Annie, et al.
Publicado: (2012)

CIINE Reflects Collagenase-Specific CII Breakdown in Cartilage Explant and Whole Body of Canine
por: Matsukawa, Satoko, et al.
Publicado: (2013)

Cartilage organoids for cartilage development and cartilage-associated disease modeling
por: Lin, Weiping, et al.
Publicado: (2023)

Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages
por: van Dierendonck, Xanthe A. M. H., et al.
Publicado: (2022)

Breakdown of clonal cooperative architecture in multispecies biofilms and the spatial ecology of predation
por: Wucher, Benjamin R., et al.
Publicado: (2023)

The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown
por: Halder, Sebok K., et al.
Publicado: (2021)

The Simultaneous Abolition of Three Starch Hydrolases Blocks Transient Starch Breakdown in Arabidopsis
por: Streb, Sebastian, et al.
Publicado: (2012)

Exploiting breakdown in nonhost effector–target interactions to boost host disease resistance
por: McLellan, Hazel, et al.
Publicado: (2022)

A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis
por: Groen, Solveig Skovlund, et al.
Publicado: (2021)

Exaggerated hypoxic vascular breakdown in aged brain due to reduced microglial vasculo‐protection
por: Halder, Sebok K., et al.
Publicado: (2022)

Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
por: Eskelinen, Atte S. A., et al.
Publicado: (2020)

Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12
por: Pérez‐García, Selene, et al.
Publicado: (2019)

Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model
por: Black, Rebecca Mae, et al.
Publicado: (2020)

Virtual Nuclear Envelope Breakdown and Its Regulators in Fission Yeast Meiosis
por: Asakawa, Haruhiko, et al.
Publicado: (2016)

Time domain simulations of preliminary breakdown pulses in natural lightning
por: Carlson, B E, et al.
Publicado: (2015)

Magnetically Actuated Manipulation and Its Applications for Cartilage Defects: Characteristics and Advanced Therapeutic Strategies
por: Zhang, Chi, et al.
Publicado: (2020)

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
por: Casas, Ana I., et al.
Publicado: (2017)

Inhibition of calcineurin by FK506 stimulates germinal vesicle breakdown of mouse oocytes in hypoxanthine-supplemented medium
por: Wang, Li, et al.
Publicado: (2017)

Role of Cytokines in Cartilage Destruction in Experimental Arthritis
por: van den Berg, Wim B
Publicado: (2000)

Allostatic breakdown of cascading homeostat systems: A computational approach
por: Acevedo, Alison, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bdcgd0klst4qoalcprolpbh7u6