Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

[Image: see text] Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2–3% of patients treated with etoposide eventually develop treatment-related acute myeloid leukemias (t-AMLs) characterized by rearrangements of the ML...

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Detalles Bibliográficos
Autores principales: Smith, Nicholas A., Byl, Jo Ann W., Mercer, Susan L., Deweese, Joseph E., Osheroff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033626/
https://www.ncbi.nlm.nih.gov/pubmed/24766193
http://dx.doi.org/10.1021/bi500421q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033626/
https://www.ncbi.nlm.nih.gov/pubmed/24766193
http://dx.doi.org/10.1021/bi500421q

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