Cargando…

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

[Image: see text] Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2–3% of patients treated with etoposide eventually develop treatment-related acute myeloid leukemias (t-AMLs) characterized by rearrangements of the ML...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smith, Nicholas A., Byl, Jo Ann W., Mercer, Susan L., Deweese, Joseph E., Osheroff, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033626/ https://www.ncbi.nlm.nih.gov/pubmed/24766193 http://dx.doi.org/10.1021/bi500421q

Ejemplares similares

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
por: Deweese, Joseph E., et al.
Publicado: (2009)

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
por: Hawtin, Rachael E., et al.
Publicado: (2010)

Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα
por: Ashley, Rachel E., et al.
Publicado: (2014)

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination
por: Heintzman, Darren R., et al.
Publicado: (2019)

Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism
por: Lindsey, R. Hunter, et al.
Publicado: (2014)

Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage
por: Deweese, Joseph E., et al.
Publicado: (2008)

No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study
por: Deweese, Joseph E., et al.
Publicado: (2023)

Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II
por: Kuriappan, Jissy A., et al.
Publicado: (2019)

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences
por: Infante Lara, Lorena, et al.
Publicado: (2018)

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
por: Schmidt, Bryan H., et al.
Publicado: (2010)

Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation
por: Furniss, Katherine L., et al.
Publicado: (2013)

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
por: Dauda, Soziema E., et al.
Publicado: (2023)

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
por: Ortega, Jose Antonio, et al.
Publicado: (2020)

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events
por: Kristoffersen, Emil L., et al.
Publicado: (2017)

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide
por: Sunter, Nicola J., et al.
Publicado: (2010)

Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase II α gene transfer is independent of topoisomerase II β
por: Zhou, Z, et al.
Publicado: (2001)

Examining the Impact of Antimicrobial Fluoroquinolones on Human DNA Topoisomerase IIα and IIβ
por: Fief, Cole A., et al.
Publicado: (2019)

Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II
por: Le, Tung T., et al.
Publicado: (2023)

Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases
por: Jian, Jeffrey Y., et al.
Publicado: (2023)

The Broken MLL Gene Is Frequently Located Outside the Inherent Chromosome Territory in Human Lymphoid Cells Treated with DNA Topoisomerase II Poison Etoposide
por: Glukhov, Sergey I., et al.
Publicado: (2013)

Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor
por: Ezoe, Sachiko
Publicado: (2012)

Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases
por: Vann, Kendra R., et al.
Publicado: (2015)

Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity
por: Schmidt, Bryan H., et al.
Publicado: (2012)

Topoisomerase IIα Binding Domains of Adenomatous Polyposis Coli Influence Cell Cycle Progression and Aneuploidy
por: Wang, Yang, et al.
Publicado: (2010)

UPR-Induced Resistance to Etoposide Is Downstream of PERK and Independent of Changes in Topoisomerase IIα Levels
por: Mann, Melissa J., et al.
Publicado: (2012)

A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase
por: Byl, Jo Ann W., et al.
Publicado: (2023)

Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-cell lung cancer.
por: Ando, M., et al.
Publicado: (1997)

Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells
por: Barthelmes, H U, et al.
Publicado: (2001)

Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.
por: Smith, P. J., et al.
Publicado: (1994)

Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.
por: Ritke, M. K., et al.
Publicado: (1994)

Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide.
por: Vassetzky, Y. S., et al.
Publicado: (1996)

Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines
por: Matsumoto, Yoshihito, et al.
Publicado: (2001)

Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy
por: Yue, Jingyin, et al.
Publicado: (2012)

Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy
por: Mehta, Amol, et al.
Publicado: (2018)

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives
por: Marinello, Jessica, et al.
Publicado: (2018)

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells
por: More, Piyush, et al.
Publicado: (2019)

Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II
por: Baldwin, E. L., et al.
Publicado: (2005)

Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice
por: Yang, Xuejiao, et al.
Publicado: (2012)

Activities of gyrase and topoisomerase IV on positively supercoiled DNA
por: Ashley, Rachel E., et al.
Publicado: (2017)

Immunodetection of human topoisomerase I-DNA covalent complexes
por: Patel, Anand G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6412a7cahqj17048lsbn3vg6eo