Acetaminophen Reactive Intermediates Target Hepatic Thioredoxin Reductase

[Image: see text] Acetaminophen (APAP) is metabolized in the liver to N-acetyl-p-benzoquinone imine (NAPQI), an electrophilic metabolite known to bind liver proteins resulting in hepatotoxicity. Mammalian thioredoxin reductase (TrxR) is a cellular antioxidant containing selenocysteine (Sec) in its C...

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Detalles Bibliográficos
Autores principales: Jan, Yi-Hua, Heck, Diane E., Dragomir, Ana-Cristina, Gardner, Carol R., Laskin, Debra L., Laskin, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033643/
https://www.ncbi.nlm.nih.gov/pubmed/24661219
http://dx.doi.org/10.1021/tx5000443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033643/
https://www.ncbi.nlm.nih.gov/pubmed/24661219
http://dx.doi.org/10.1021/tx5000443

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