Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu(2/3)) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and Assessment in a Rat Model of Cocaine Dependence

[Image: see text] As part of our ongoing small-molecule metabotropic glutamate (mGlu) receptor positive allosteric modulator (PAM) research, we performed structure–activity relationship (SAR) studies around a series of group II mGlu PAMs. Initial analogues exhibited weak activity as mGlu(2) receptor...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhanya, Raveendra-Panickar, Sheffler, Douglas J., Dahl, Russell, Davis, Melinda, Lee, Pooi San, Yang, Li, Nickols, Hilary Highfield, Cho, Hyekyung P., Smith, Layton H., D’Souza, Manoranjan S., Conn, P. Jeffrey, Der-Avakian, Andre, Markou, Athina, Cosford, Nicholas D. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033659/
https://www.ncbi.nlm.nih.gov/pubmed/24735492
http://dx.doi.org/10.1021/jm5000563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033659/
https://www.ncbi.nlm.nih.gov/pubmed/24735492
http://dx.doi.org/10.1021/jm5000563

Ejemplares similares