Cargando…

Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

[Image: see text] Tumor growth is fueled by the use of glycolysis, which normal cells use only in the scarcity of oxygen. Glycolysis makes tumor cells resistant to normal death processes. Targeting this unique tumor metabolism can provide an alternative strategy to selectively destroy the tumor, lea...

Descripción completa

Detalles Bibliográficos
Autores principales: Pathak, Rakesh K., Marrache, Sean, Harn, Donald A., Dhar, Shanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033660/
https://www.ncbi.nlm.nih.gov/pubmed/24617941
http://dx.doi.org/10.1021/cb400944y