3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

[Image: see text] Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins, is a validated and attractive target for cancer therapy. Overexpression of Mcl-1 in many cancers results in disease progression and resistance to current chemotherapeutics. Utilizing high-throughput screening, compound...

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Detalles Bibliográficos
Autores principales: Abulwerdi, Fardokht A., Liao, Chenzhong, Mady, Ahmed S., Gavin, Jordan, Shen, Chenxi, Cierpicki, Tomasz, Stuckey, Jeanne A., Showalter, H. D. Hollis, Nikolovska-Coleska, Zaneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033665/
https://www.ncbi.nlm.nih.gov/pubmed/24749893
http://dx.doi.org/10.1021/jm500010b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033665/
https://www.ncbi.nlm.nih.gov/pubmed/24749893
http://dx.doi.org/10.1021/jm500010b

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