LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains executing several functions, including GTP hydrolysis, kinase activity, and protein binding. Robust evidence su...

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Detalles Bibliográficos
Autores principales: Cirnaru, Maria D., Marte, Antonella, Belluzzi, Elisa, Russo, Isabella, Gabrielli, Martina, Longo, Francesco, Arcuri, Ludovico, Murru, Luca, Bubacco, Luigi, Matteoli, Michela, Fedele, Ernesto, Sala, Carlo, Passafaro, Maria, Morari, Michele, Greggio, Elisa, Onofri, Franco, Piccoli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034499/
https://www.ncbi.nlm.nih.gov/pubmed/24904275
http://dx.doi.org/10.3389/fnmol.2014.00049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034499/
https://www.ncbi.nlm.nih.gov/pubmed/24904275
http://dx.doi.org/10.3389/fnmol.2014.00049

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