Investigating the Dynamic Aspects of Drug-Protein Recognition through a Combination of MD and NMR Analyses: Implications for the Development of Protein-Protein Interaction Inhibitors

In this paper, we investigate the dynamic aspects of the molecular recognition between a small molecule ligand and a flat, exposed protein surface, representing a typical target in the development of protein-protein interaction inhibitors. Specifically, we analyze the complex between the protein Fib...

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Detalles Bibliográficos
Autores principales: Meli, Massimiliano, Pagano, Katiuscia, Ragona, Laura, Colombo, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035249/
https://www.ncbi.nlm.nih.gov/pubmed/24865844
http://dx.doi.org/10.1371/journal.pone.0097153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035249/
https://www.ncbi.nlm.nih.gov/pubmed/24865844
http://dx.doi.org/10.1371/journal.pone.0097153

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