The mTOR Inhibitor Rapamycin Synergizes with a Fatty Acid Synthase Inhibitor to Induce Cytotoxicity in ER/HER2-Positive Breast Cancer Cells

Patients with ER/HER2-positive breast cancer have a poor prognosis and are less responsive to selective estrogen receptor modulators; this is presumably due to the crosstalk between ER and HER2. Fatty acid synthase (FASN) is essential for the survival and maintenance of the malignant phenotype of br...

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Detalles Bibliográficos
Autores principales: Yan, Chen, Wei, Huang, Minjuan, Zheng, Yan, Xue, Jingyue, Yang, Wenchao, Liu, Sheng, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035285/
https://www.ncbi.nlm.nih.gov/pubmed/24866893
http://dx.doi.org/10.1371/journal.pone.0097697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035285/
https://www.ncbi.nlm.nih.gov/pubmed/24866893
http://dx.doi.org/10.1371/journal.pone.0097697

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