Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Greater than 160 missense mutations in copper-zinc superoxide dismutase-1 (SOD1) can cause amyotrophic lateral sclerosis (ALS). These mutations produce conformational changes that reveal novel antibody binding epitopes. A monoclonal antibody, clone C4F6 - raised against the ALS variant G93A of SOD1,...

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Detalles Bibliográficos
Autores principales: Ayers, Jacob I, Xu, Guilian, Pletnikova, Olga, Troncoso, Juan C, Hart, P John, Borchelt, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035506/
https://www.ncbi.nlm.nih.gov/pubmed/24887207
http://dx.doi.org/10.1186/2051-5960-2-55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035506/
https://www.ncbi.nlm.nih.gov/pubmed/24887207
http://dx.doi.org/10.1186/2051-5960-2-55

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